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Delirium after interleukin-2 and alpha-interferon therapy for renal cell carcinoma
J H van Steijn1, P Nieboer, G A Hospers
1Department of Medical Oncology, University Hospital Groningen, The Netherlands. j.h.m.van.steijn@int.azg.nl
Anticancer Research
|February 19, 2002
Abstract:
A 55-year-old man receiving alpha-interferon and interleukin-2 therapy for renal cell carcinoma presented with seizures and delirium. A CT-scan of the cerebrum did not reveal any disorder. Both alpha-interferon and interleukin-2 were stopped. Treatment with steroids led to complete regression of central nervous system symptomatology. We emphasize the importance of ruling out iatrogenesis in patients treated with alpha-interferon and/or interleukin-2 who display neuropsychiatric symptoms.