Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Severe decrease in peripheral blood dendritic cells in hairy cell leukaemia.

Anne Bourguin-Plonquet1, Hélène Rouard, Françoise Roudot-Thoraval

  • 1Service d'Immunologie Biologique, Hôpital Henri Mondor, Créteil, France. anne.plonquet@hmn.ap-hop-paris.fr

British Journal of Haematology
|February 19, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dried Blood Spot: A Tool to Ensure Broad Access to Hepatitis D Screening, Diagnosis, and Treatment Monitoring.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

Targeted knockdown of Smn in muscle stem cells induces non-cell autonomous loss of motor neurons.

Brain : a journal of neurology·2026
Same author

Directly Thawed Bone Marrow Mesenchymal Stromal Cells Retain Mechanism of Action and Support Bone Clinical Translation.

Stem cell reviews and reports·2025
Same author

Tracheobronchial Replacement Using Cryopreserved Aortic Allografts: Results in 50 Patients (TRITON-01 Registry).

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2025
Same author

The Viral Hepatitis Prevention Board (VHPB) supports the continued recommendation for universal hepatitis B vaccination of all newborns within 24 hours of birth.

Human vaccines & immunotherapeutics·2025
Same author

Securing raw materials, reagents, and consumable supplies in the academic bioproduction UNITC network: because the chain is only as strong as its weakest link.

Bone marrow transplantation·2025
Same journal

The Endothelial Activation and Stress Index (EASIX) at diagnosis is associated with survival in primary central nervous system lymphoma.

British journal of haematology·2026
Same journal

Hyperlactataemia in lymphoma-associated haemophagocytic lymphohistiocytosis: Linked to monocytic glycolysis and adverse prognosis.

British journal of haematology·2026
Same journal

Clinical outcomes of the chemo-free approach in relapsed/refractory follicular lymphoma: A network meta-analysis.

British journal of haematology·2026
Same journal

Early venetoclax dose escalation at minimal residual disease progression may benefit selected acute myeloid leukaemia patients.

British journal of haematology·2026
Same journal

Evaluating high-sensitivity troponin levels in people with sickle cell disease in the emergency department.

British journal of haematology·2026
Same journal

Methaemoglobinaemia: From pathophysiology to contemporary clinical management.

British journal of haematology·2026
See all related articles

Hairy cell leukaemia (HCL) patients show a severe deficiency in dendritic cells (DC) and monocytes, impacting the immune system. These crucial immune cells slowly recover after treatment, suggesting impaired antigen presentation contributes to infection susceptibility in HCL.

Area of Science:

  • Immunology
  • Hematology
  • Oncology

Background:

  • Clinical studies in hairy cell leukaemia (HCL) report frequent infections by intracellular pathogens.
  • A profound monocytopenia is a common finding in HCL patients.
  • Dendritic cells (DC), derived from monocytes, are professional antigen-presenting cells vital for adaptive immunity.

Purpose of the Study:

  • To investigate the status of dendritic cell (DC) subsets and monocytes in the peripheral blood of HCL patients.
  • To determine if these immune cells are impaired in HCL and correlate with infection susceptibility.

Main Methods:

  • Peripheral blood samples were analyzed from HCL patients with active disease.
  • Membrane markers and flow cytometry were utilized to identify and quantify DC subsets and monocytes.

Related Experiment Videos

Main Results:

  • Lymphoid and myeloid dendritic cells (DC) were virtually absent in HCL patients with active disease.
  • Monocytes were also found to be significantly reduced.
  • Following treatment, both DC and monocytes showed slow recovery.

Conclusions:

  • The substantial decrease in dendritic cells (DC) in HCL patients suggests impaired antigen presentation.
  • Defective antigen presentation may contribute to the increased susceptibility to intracellular infections observed in HCL.
  • Restoration of DC and monocyte populations is crucial for immune recovery in HCL.