Related Experiment Video
Updated: Oct 2, 2026

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
Published on: February 25, 2016
Nitric oxide drives skin repair: novel functions of an established mediator
Stefan Frank1, Heiko Kämpfer, Christian Wetzler
1Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt/Main, Theodor-Stern-Kai, D-60590 Frankfurt am Main, Germany. S.Frank@em.uni-frankfurt.de
Abstract:
Wound healing of the skin represents a highly ordered process of important tissue movements that aims for a rapid closure of the wound site and a subsequent regeneration of the injured tissue. The factors ensuring the intercellular communication during repair are only known in part. However, although protein-type mediators are well-established players in this process, it has become evident that the diffusible, gaseous molecule nitric oxide (NO) participates in the orchestration of wound healing. The role of wound-derived NO that critically influences macrophage, fibroblast, and keratinocyte behaviour within the intercellular communication network during repair is subject of this review. Thus, cutaneous wound healing prototypically reflects processes that generally occur also in kidney injury and regeneration.
More Related Videos
08:23Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
08:32Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
Related Concept Videos
Nitric Oxide Signaling Pathway
Paracrine Signaling
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation I: Inflammatory Response
Inflammation