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Related Experiment Videos

Enhanced renal cortical vascularization in experimental hypercholesterolemia.

Michael D Bentley1, Martin Rodriguez-Porcel, Amir Lerman

  • 1Department of Internal Medicine, Division of Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Kidney International
|February 19, 2002
PubMed
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High cholesterol in pigs increased small blood vessel density in the kidney cortex, preceding visible damage. This finding suggests potential impacts on kidney blood flow regulation and disease progression.

Area of Science:

  • Nephrology
  • Cardiovascular Science
  • Medical Imaging

Background:

  • Hypercholesterolemia is linked to inflammation and altered tissue perfusion, potentially causing neovascularization.
  • The effect of hypercholesterolemia on renal microvasculature remains largely uncharacterized.
  • This study investigates hypercholesterolemia-induced changes in renal microvascular density.

Purpose of the Study:

  • To test the hypothesis that hypercholesterolemia is associated with increased microvascular density in the renal cortex.
  • To evaluate early vascular changes in the kidney due to diet-induced hypercholesterolemia.

Main Methods:

  • Kidneys from pigs on normal or high-cholesterol diets were analyzed after 12 weeks.
  • A novel 3-D micro computed-tomography technique was employed for microvessel analysis.

Related Experiment Videos

  • Microvessels (80-360 micrometers) in the renal cortex were quantified in situ.

    • Main Results:

    • Hypercholesterolemic pigs exhibited significantly higher serum cholesterol levels.
    • A significant increase in microvascular spatial density was observed in the inner and middle renal cortex of hypercholesterolemic pigs.
    • Early hypercholesterolemia showed mild interstitial inflammation and increased vascular endothelial growth factor staining without overt morphological damage.

    Conclusions:

    • Diet-induced hypercholesterolemia is associated with increased renal cortical microvascular density.
    • These vascular changes occur before evident morphological damage to the kidney.
    • The findings suggest potential alterations in intrarenal blood flow regulation and a role in renal disease progression.