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Related Experiment Videos

Functional genomics and target validation approaches using antisense oligonucleotide technology.

N M Dean1

  • 1Department of Functional Genomics, GeneTrove (a division of Isis Pharmaceuticals), 2292 Faraday Avenue, Carlsbad, CA 92008, USA. nick_dean@isisph.com

Current Opinion in Biotechnology
|February 19, 2002
PubMed
Summary
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Genomic data growth presents challenges for drug discovery. Antisense technology aids in identifying disease genes and validating drug targets for new pharmaceuticals.

Area of Science:

  • Genomics
  • Pharmacology
  • Molecular Biology

Background:

  • The pharmaceutical industry faces challenges in leveraging the rapidly increasing volume of genomic data.
  • Efficiently identifying genes linked to complex diseases and developing targeted drugs is crucial.

Purpose of the Study:

  • To explore the utility of antisense technology in addressing challenges in pharmaceutical research and development.
  • To identify novel cellular networks and signaling pathways for drug target validation.

Main Methods:

  • Utilizing antisense technology to investigate gene function and cellular networks.
  • In vivo validation of identified genes as potential drug targets.

Main Results:

  • Antisense technology enables the identification of novel cellular signaling "cassettes".

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  • This approach facilitates the validation of genes as viable drug targets within a biological system.

    • Conclusions:

    • Antisense technology is a powerful tool for the pharmaceutical industry to navigate genomic data.
    • It offers a robust method for discovering and validating drug targets for complex diseases.