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Complex karyotype in a low grade phyllodes tumor of the breast
James Ladesich1, Ivan Damjanov, Diane Persons
1Department of Surgical Pathology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA. jladesich@kumc.edu
Cancer Genetics and Cytogenetics
|February 19, 2002
Abstract:
Cytogenetic analysis of a phyllodes tumor of low grade malignancy disclosed the karyotype 52-55,XX, -1,+5,+7,+9,+10,+11,-15,+18,-19,+20,der(21)t(1;21)(p13;q22),+mar1x 2-4,+mar2[cp18]/46,XX. This study shows that a complex chromosome karyotype can be found in low-grade phyllodes tumors and is not necessarily a sign of extreme malignancy of these neoplasms.