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Chronic lymphocytic leukemia with a novel der(8;15)(q10;q10) translocation
1Department of Pathology, Queen Elizabeth Hospital, SAR, Hong Kong, China. kfwong@ha.org.hk
Cancer Genetics and Cytogenetics
|February 19, 2002
Abstract:
A 71-year-old male was found to have chronic lymphocytic leukemia. Cytogenetic study of the leukemic lymphocytes shows a 46,XY,der(8;15)+15. The der(8;15) is a novel chromosomal abnormality in human malignancies. The resulting loss of 8p and trisomy 15q are both unusual chromosomal changes in chronic lymphocytic leukemia.