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Mitochondrial dysfunction in progressive supranuclear palsy.

David S Albers1, M Flint Beal

  • 1Department of Neurology and Neuroscience, Weill Medical College, Cornell University, Room A-503, 525 East 68th Street, New York, NY 10021, USA. daa2010@mail.med.cornell.edu

Neurochemistry International
|February 19, 2002
PubMed
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Mitochondrial dysfunction contributes to neurodegenerative diseases like Parkinson's and Alzheimer's. This study suggests bio-energetic defects are involved in the pathogenesis of progressive supranuclear palsy (PSP).

Area of Science:

  • Neuroscience
  • Mitochondrial Biology
  • Neuropathology

Background:

  • Mitochondrial dysfunction is implicated in neurodegenerative diseases such as Parkinson's, Alzheimer's, and Huntington's.
  • Dysfunctional mitochondria can lead to impaired calcium buffering, free radical generation, and excitotoxicity.
  • Progressive supranuclear palsy (PSP) is a rare neurological disorder with unknown etiology, characterized by gaze palsy and extrapyramidal symptoms.

Purpose of the Study:

  • To investigate the role of bio-energetic defects in the pathogenesis of progressive supranuclear palsy (PSP).

Main Methods:

  • Spectroscopy studies in PSP patients.
  • Biochemical studies in post-mortem PSP brain tissue.
  • Analysis of PSP cybrids.

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Main Results:

  • Evidence suggests a contributory role of bio-energetic defects in PSP pathogenesis.
  • Findings support the involvement of mitochondrial dysfunction in PSP.

Conclusions:

  • Bio-energetic deficits are likely involved in the development of progressive supranuclear palsy.
  • Further research into mitochondrial function in PSP is warranted.