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Penetration of rifampin through Staphylococcus epidermidis biofilms
Zhilan Zheng1, Philip S Stewart
1Center for Biofilm Engineering and Department of Chemical Engineering, Montana State University-Bozeman, Bozeman, Montana 59717-3980, USA.
Antimicrobial Agents and Chemotherapy
|February 19, 2002
Abstract:
Rifampin penetrated biofilms formed by Staphylococcus epidermidis but failed to effectively kill the bacteria. Penetration was demonstrated by a simple diffusion cell bioassay and by transmission electron microscopic observation of antibiotic-affected cells at the distal edge of the biofilm.