Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventricle-directed migration in the developing cerebral cortex.

Bagirathy Nadarajah1, Pavlos Alifragis, Rachel O L Wong

  • 1Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.

Nature Neuroscience
|February 19, 2002
PubMed
Summary

Contrary to popular belief, developing neurons migrate towards the cortical ventricular zone, not away. These GABAergic interneurons pause before migrating radially to the cortical plate, challenging established models of neuronal migration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Innervation Pattern of Inhibitory Projection Neurons in the Bird Sound Localization Circuit.

The Journal of comparative neurology·2026
Same author

Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina.

eLife·2025
Same author

Targeted splicing approach for alleviation of a neurexin 1 haploinsufficiency model.

Molecular psychiatry·2025
Same author

A presynaptic source drives differing levels of surround suppression in two mouse retinal ganglion cell types.

Nature communications·2024
Same author

Defect patterns on the curved surface of fish retinae suggest a mechanism of cone mosaic formation.

PLoS computational biology·2020
Same author

Attenuating the DNA damage response to double-strand breaks restores function in models of CNS neurodegeneration.

Brain communications·2020

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Migration

Background:

  • Postmitotic neurons are traditionally thought to migrate away from germinal zones to distant targets.
  • The precise migratory paths and cues guiding neuronal populations in the developing neocortex remain incompletely understood.

Purpose of the Study:

  • To investigate the migratory behavior of neurons in the developing neocortex.
  • To identify the origin and type of neurons exhibiting unconventional migratory patterns.
  • To explore potential mechanisms and functional implications of ventricle-directed neuronal migration.

Main Methods:

  • Time-lapse imaging of brain slices to observe neuronal migration in real-time.
  • Immunohistochemical analysis to identify cell types.

Related Experiment Videos

  • Tracer labeling in brain slices to track cell origins and migratory routes.

    • Main Results:

    • Identified populations of neurons migrating towards the cortical ventricular zone, challenging the conventional outward migration model.
    • Demonstrated that these migrating cells are GABAergic interneurons originating from the ventral telencephalon's ganglionic eminence.
    • Observed a migratory pattern involving an initial ventricle-directed phase followed by radial migration towards the cortical plate.

    Conclusions:

    • Neuronal migration in the developing neocortex is more complex than previously assumed, involving ventricle-directed movement.
    • GABAergic interneurons utilize this unique migratory pathway, potentially to acquire positional information in the cortical ventricular zone.
    • Chemoattractant and chemorepellent molecules are likely involved in guiding this specific ventricle-directed migration.