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Parental [correction of Perinatal] consanguinity: a risk factor for developmental delay in Pakistani children
Insights
Parental consanguinity was studied for its link to developmental delays in children. The study found no increased risk of developmental delays in gross motor, fine motor, speech, or social skills associated with parental consanguinity.
Area of Science:
- Pediatric Development
- Genetics
- Public Health
Background:
- Parental consanguinity, the mating of related individuals, is a known factor influencing the prevalence of autosomal recessive disorders.
- Understanding its impact on general child development is crucial for genetic counseling and public health initiatives.
Purpose of the Study:
- To investigate the association between parental consanguinity and developmental delays in children.
- To assess delays across gross motor, fine motor, speech, and social domains.
Main Methods:
- An unmatched case-control study involving 177 children (15 days–72 months).
- Developmental status assessed using the Denver Developmental Screening Test (DDST).
- Binary Multiple Logistic Regression Analysis used to calculate odds ratios for parental consanguinity and developmental delays, excluding acquired delays.
Main Results:
- Univariate analysis indicated significant odds ratios for developmental delays in all assessed areas (gross motor, fine motor, speech, social) between cases and controls (p < .001).
- Multivariate analysis revealed no statistically significant increased risk of parental consanguinity associated with delayed gross motor, fine motor, speech, or social development in children.
Conclusions:
- The study concludes that parental consanguinity does not pose an increased risk for delayed gross motor, fine motor, speech, or social development in children, as measured by the DDST.
- These findings suggest that while consanguinity increases the risk for specific genetic disorders, it may not broadly impact general developmental milestones.
Objective:
To investigate the association of parental consanguinity and delayed development in terms of gross motor, fine motor, speech and social aspects in their children.
Methods:
One hundred and seventy seven children (age 15 days--72 months) were evaluated for their developmental status utilizing the Denver Developmental Screening Test (DDST). An unmatched case-control study design was used. Case group consisted of 94 children and control group 83 children. Odds ratios were calculated for parental consanguinity and delay in gross and fine motor, speech and social development in their children, for cases and controls, utilizing Binary Multiple Logistic Regression Analysis. Acquired delay was excluded through detailed birth history in both cases and control group respectively.
Results:
Univariate analysis showed high significant Odds ratios for all areas of developmental delay (viz. gross and fine motor, speech and social development), between cases and controls (p < .001). At the multivariate analysis level however, our results showed no increased risk of parental consanguinity on delayed gross and fine motor, speech and social development in their children.
Conclusion:
Our results show no increased risk of parental consanguinity on delayed gross and fine motor, speech or social development (as measured by the DDST), in their children.