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Decreased nocturnal urinary antidiuretic hormone excretion in enuresis is increased by imipramine

P A Tomasi1, S Siracusano, A M Monni

  • 1Università di Sassari, Istituto di Patologia Speciale Medica, Italy. tomasi@uniss.it

BJU International
|February 20, 2002
PubMed

Insights

Children with enuresis show lower nocturnal antidiuretic hormone (ADH) excretion. Imipramine treatment normalized ADH levels and improved biochemical markers in enuretic children.

Area of Science:

  • Pediatric Endocrinology
  • Urology
  • Nephrology

Background:

  • Nocturnal antidiuretic hormone (ADH) secretion plays a role in regulating urine production.
  • Enuresis, or bedwetting, is a common condition in children with complex underlying mechanisms.
  • Understanding ADH secretion patterns is crucial for effective enuresis management.

Purpose of the Study:

  • To investigate the role of integrated nocturnal antidiuretic hormone (ADH) secretion in children experiencing enuresis.
  • To evaluate the impact of imipramine treatment on nocturnal ADH secretion and related biochemical parameters in enuretic children.

Main Methods:

  • Measured morning plasma ADH and nocturnal urinary ADH concentrations in 18 enuretic children and 21 controls.
  • Assessed diurnal and nocturnal urine production, plasma and urinary osmolality.
  • Repeated assessments after 14 days of 20 mg/night oral imipramine hydrochloride treatment.

Main Results:

  • Enuretic children exhibited significantly lower nocturnal urinary ADH integrated concentrations compared to controls.
  • Imipramine treatment led to a significant increase in plasma ADH levels and nocturnal urinary ADH concentrations.
  • Treatment with imipramine also resulted in decreased morning plasma osmolality and reduced 24-hour fluid intake.

Conclusions:

  • Enuretic children demonstrate reduced nocturnal antidiuretic hormone (ADH) excretion.
  • Imipramine effectively restores nocturnal ADH excretion and elevates morning plasma ADH levels.
  • Imipramine treatment induces consistent beneficial changes in other biochemical variables related to enuresis.
Abstract

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