Related Experiment Video
Updated: Jul 31, 2026
06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Sarcomatoid transitional cell carcinoma originating from a duplicated renal pelvis
T Hisataki1, A Takahashi, K Taguchi
1Department of Urology, Sunagawa City Medical Center, Sunagawa, Japan. hisataki@sapmed.ac.jp
Summary
This report details a rare sarcomatoid transitional cell carcinoma of the renal pelvis. Immunohistochemistry distinguished it from carcinosarcoma, aiding diagnosis in complex imaging cases.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Transitional cell carcinoma (TCC) can exhibit sarcomatoid features, posing diagnostic challenges.
- Renal pelvis tumors require accurate differentiation from parenchymal lesions for appropriate management.
Observation:
- A unique case of sarcomatoid TCC originating from a duplicated renal pelvis is presented.
- Imaging studies complicated the distinction between this renal pelvis tumor and a renal parenchymal tumor.
Findings:
- Immunohistochemical analysis was crucial in differentiating the sarcomatoid TCC from carcinosarcoma.
- The tumor's origin in a duplicated renal pelvis contributed to its challenging presentation on imaging.
Implications:
- Accurate diagnosis of sarcomatoid TCC is vital for patient prognosis and treatment planning.
- This case highlights the importance of advanced diagnostic techniques, like immunohistochemistry, in challenging oncological presentations.
- Understanding the impact of renal anomalies on tumor presentation can improve diagnostic accuracy.
More Related Videos
Related Concept Videos
02:21Cancers Originate from Somatic Mutations in a Single Cell
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
02:30Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:22Ureters
The ureters are retroperitoneal tubes located on either side of the vertebral column. They are responsible for transporting urine from each kidney to the urinary bladder. These tubes have thick walls and are approximately 25-30 cm long. Their diameter is around 10 mm at the renal pelvis, gradually narrowing to 1 mm as the ureter obliquely enters the posterior bladder wall through the ureteric orifices. The shape of these orifices is slit-like, which helps to prevent urine backflow toward the...
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...