Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Catheter thrombosis.

G A Beathard1

  • 13805 Green Trails South, Austin, Texas 78731, USA. gerald@beathard.com

Seminars in Dialysis
|February 20, 2002
PubMed
Summary
This summary is machine-generated.

Catheter malfunction, often caused by fibrin sheath thrombus, requires prompt treatment to ensure adequate dialysis. While urokinase is unavailable, recombinant tissue plasminogen activator (tPA) shows promise, but catheter exchange remains the current best solution.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recognition of the failing vascular access: a current perspective.

Seminars in dialysis·2009
Same author

Initial clinical results with the LifeSite Hemodialysis Access System.

Kidney international·2000
Same author

Strategy for maximizing the use of arteriovenous fistulae.

Seminars in dialysis·2000
Same author

Management of bacteremia associated with tunneled-cuffed hemodialysis catheters.

Journal of the American Society of Nephrology : JASN·1999
Same author

Salvage of the nonfunctioning arteriovenous fistula.

American journal of kidney diseases : the official journal of the National Kidney Foundation·1999
Same author

Surgical management of thrombosed dialysis access grafts.

American journal of kidney diseases : the official journal of the National Kidney Foundation·1998
Same journal

Intracardiac Vascular Access for Hemodialysis Despite Associated Ascending Aortic Aneurysm.

Seminars in dialysis·2026
Same journal

Measures of Equivalent Hemodialysis Urea Clearance and Their Proposed Utility for Monitoring Adequacy.

Seminars in dialysis·2026
Same journal

Risk of Serious Adverse Events and Death With Low-Dose Methotrexate Versus Hydroxychloroquine in Adults Receiving Dialysis.

Seminars in dialysis·2026
Same journal

Severe Hematoma Following Initial Arteriovenous Fistula Puncture in a Hemodialysis Patient, Emphasizing Thoracic Outlet Syndrome: A Case Report.

Seminars in dialysis·2026
Same journal

Phosphate Kinetic Modeling in Patients Treated With Hemodialysis or Hemodiafiltration: A Prospective, Multicenter, Cross-Sectional Study.

Seminars in dialysis·2026
Same journal

Impact of Expanded Hemodialysis on Inflammation and Iron Metabolism in Chronic Hemodialysis Patients.

Seminars in dialysis·2026
See all related articles

Area of Science:

  • Nephrology
  • Vascular Access Management

Background:

  • Catheter malfunction, particularly due to poor flow, is a frequent complication in dialysis.
  • Early malfunctions are typically technical, while late issues often stem from thrombus formation, most commonly the fibrin sheath thrombus.

Purpose of the Study:

  • To review the causes and management of catheter malfunction in dialysis.
  • To explore potential therapeutic alternatives following the unavailability of urokinase.

Main Methods:

  • Literature review on catheter malfunction causes and treatments.
  • Discussion of thrombus types and formation mechanisms.
  • Evaluation of recombinant tissue plasminogen activator (tPA) as a potential alternative.

Main Results:

Related Experiment Videos

  • Fibrin sheath thrombus is the most prevalent cause of late catheter malfunction.
  • Urokinase, a previous treatment, is no longer available.
  • Recombinant tissue plasminogen activator (tPA) is a potential but not optimally packaged alternative.

Conclusions:

  • Prompt treatment of catheter malfunction is crucial to prevent inadequate dialysis.
  • Catheter exchange is currently the most reliable management strategy for catheter malfunction.
  • Further development of tPA packaging is needed for optimal use in this context.