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HTLV antibody screening using mini-pools.

B C Dow1, H Munro, K Ferguson

  • 1Scottish National Blood Transfusion Service Microbiology Reference Unit, West of Scotland Blood Transfusion Centre, 25 Shelley Road, Glasgow G12 0XB, UK. brian.dow@snbts.csa.scot.nhs.uk

Transfusion Medicine (Oxford, England)
|February 20, 2002
PubMed
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UK blood services are piloting Human T-lymphotropic virus (HTLV) antibody screening. A pilot study found a minimum HTLV prevalence of 1:95,000 among Scottish and Northern Irish blood donors, demonstrating screening feasibility.

Area of Science:

  • Transfusion Medicine
  • Virology
  • Public Health

Background:

  • The UK currently does not screen blood donations for Human T-lymphotropic virus (HTLV).
  • Assessing HTLV prevalence and screening feasibility is crucial for blood safety.
  • This study focuses on donor populations in Scotland and Northern Ireland.

Purpose of the Study:

  • To evaluate the feasibility of implementing HTLV antibody screening in blood donations using mini-pools.
  • To estimate the prevalence of HTLV infection within the Scottish and Northern Irish blood donor population.

Main Methods:

  • A pilot study utilized the Abbott/Murex HTLV I/II GE80/81 ELISA assay.
  • Mini-pools of up to 95 donations, originally prepared for HCV NAT testing, were screened.
  • Confirmed HTLV positive samples were used for dilution testing to establish assay cut-offs and grey-zone parameters.

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Main Results:

  • Out of 6666 mini-pools (570,609 donations), six showed repeated reactivity and were confirmed positive for HTLV antibodies.
  • Confirmed HTLV types included HTLV-I (four), HTLV-II (one), and untyped HTLV (one).
  • The minimum HTLV donor prevalence was determined to be 1:95,000, with no confirmed positives from grey-zone results.

Conclusions:

  • HTLV antibody screening using mini-pools is feasible for blood donations in the UK.
  • The study establishes a minimum HTLV prevalence of 1:95,000 in Scottish and Northern Irish blood donors.
  • Findings support the potential implementation of routine HTLV screening to enhance blood supply safety.