Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular prion protein: on the road for functions.

Vilma R Martins1, Rafael Linden, Marco A M Prado

  • 1Centro de Tratamento e Pesquisa Hospital do Càncer, SP, São Paulo, Brazil. vmartins@ludwig.org.br

FEBS Letters
|February 20, 2002
PubMed
Summary

Cellular prion protein (PrPc) has vital roles in neurons and other cells, influencing copper uptake, oxidative stress, and cell survival. Loss of PrPc function may contribute to various diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

STIP1/HOP promotes the formation of cytotoxic α-synuclein oligomers.

Molecular neurodegeneration advances·2026
Same author

Loss of α7 nicotinic acetylcholine receptor exacerbates adrenergic-induced cardiac damage.

American journal of physiology. Cell physiology·2026
Same author

Impairment in stimulus-response learning as a cognitive biomarker in a model of synucleinopathy.

Translational psychiatry·2026
Same author

MRI investigation of orientation-dependent changes in microstructure and function in a mouse model of mild traumatic brain injury.

Acta neuropathologica communications·2025
Same author

Stress-inducible phosphoprotein 1 (STIP1) is a critical stemness regulator in mouse embryonic stem cells and early mammalian development.

Communications biology·2025
Same author

A Longitudinal Study of Sex Differences in a TDP-43 Mouse Model Reveals STI1 Regulation of TDP-43 Proteinopathy and Motor Deficits.

Journal of neurochemistry·2025

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Cellular prion protein (PrPc) is a glycosylphosphatidylinositol-anchored protein found on the plasma membrane of neurons and other cell types.
  • Its conservation across species suggests significant physiological functions.
  • PrPc is implicated in diverse cellular processes.

Purpose of the Study:

  • To investigate the novel features of PrPc expression and trafficking.
  • To explore the physiological roles of PrPc in cellular functions.
  • To understand the potential contribution of PrPc dysfunction to disease.

Main Methods:

  • Utilized cellular and molecular approaches.
  • Examined PrPc expression and cellular trafficking.
  • Investigated PrPc's involvement in copper uptake and cellular signaling.

Related Experiment Videos

Main Results:

  • Identified novel regulatory mechanisms for PrPc expression and trafficking.
  • Demonstrated PrPc's participation in copper uptake, oxidative stress protection, cell adhesion, differentiation, signaling, and survival.
  • Established pleiotropic roles for PrPc in both neuronal and non-neuronal cells.

Conclusions:

  • PrPc plays multifaceted roles in cellular physiology.
  • Dysfunction or loss of PrPc may be a key factor in the pathogenesis of various diseases.
  • Further research into PrPc's functions is warranted.