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Related Experiment Videos

Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL

F G Gbaguidi1, G Chinetti, D Milosavljevic

  • 1UR. 545 INSERM and Université de Lille 2, Lille, France.

FEBS Letters
|February 20, 2002
PubMed
Summary

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Peroxisome proliferator-activated receptors (PPARs) influence lipoprotein lipase (LPL) in human monocytes. PPAR activation increases LPL mRNA but decreases its activity, potentially impacting atherosclerosis in diabetes.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • Lipoprotein lipase (LPL) mediates macrophage uptake of various LDL types.
  • Peroxisome proliferator-activated receptors (PPARs) are key regulators of cholesterol homeostasis in macrophages.

Purpose of the Study:

  • To investigate the role of PPARs in regulating LPL expression and activity in human monocytes and macrophages.

Main Methods:

  • Human monocytes and macrophages were incubated with PPARalpha or PPARgamma ligands.
  • LPL mRNA, intracellular protein, secreted mass, and enzyme activity were measured.

Main Results:

  • PPAR activators increased LPL mRNA and intracellular protein levels in monocytes and macrophages.
  • Conversely, PPAR activators decreased secreted LPL mass and enzyme activity in differentiated macrophages.

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  • These changes correlated with reduced uptake of glycated LDL.

    • Conclusions:

    • PPARs differentially regulate LPL expression and activity in human monocytes/macrophages.
    • PPAR-mediated modulation of LPL may influence the development of atherosclerosis, particularly in diabetic conditions.