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Serine (threonine) phosphatase(s) acting on cAMP-dependent phosphoproteins in mammalian mitochondria
Anna Signorile1, Anna Maria Sardanelli, Rosanna Nuzzi
1Department of Medical Biochemistry and Biology, University of Bari, Piazza G. Cesare-Policlinico, 70125, Bari, Italy.
FEBS Letters
|February 20, 2002
Abstract:
Immunochemical and functional evidence showing the existence in the inner membrane and matrix fraction of mammalian mitochondria of serine/threonine phosphatases acting on cAMP-dependent phosphoproteins is presented. Mg(2+)-dependent Ca(2+)-inhibitable PP2C phosphatase, associated to the inner membrane, dephosphorylates the 18 kDa (NDUFS4 gene) of complex I.