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Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation
1Dept of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA. vadim_arshavsky@meei.harvard.edu
Trends in Neurosciences
|February 20, 2002
Abstract:
Rhodopsin phosphorylation has provided one of the first examples of the ubiquitous regulatory pattern of specific kinases downregulating the activity of G-protein-coupled receptors. However, only recently have studies in living animals allowed us to consider the role of rhodopsin phosphorylation in a broader spectrum of visual functions, ranging from the ability of rods to generate reproducible electrical responses to their ability to adapt to darkness after substantial light exposures.