Pho85 and signaling environmental conditions
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Updated: Oct 2, 2026

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
Published on: April 17, 2021
Adam S Carroll1, Erin K O'Shea
1Department of Biochemistry and Biophysics and the Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143-0448, USA.
Abstract:
Through its association with a family of ten cyclins, the Pho85 cyclin-dependent kinase is involved in several signal transduction pathways in the yeast Saccharomyces cerevisiae. The responses mediated by Pho85 include cell-cycle progression and metabolism of nutrients such as phosphate and carbon sources. Although these responses require the phosphorylation of different substrates, and have different mechanistic consequences as a result of this phosphorylation, all appear to be involved in responses to changes in environmental conditions. Few of the activating signals or regulated targets have been unambiguously identified, but the kinase activity of Pho85 appears to inform the cell that the current environment is satisfactory.
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