Vascular progenitors: from biology to treatment

Aernout Luttun¹, Geert Carmeliet, Peter Carmeliet

¹Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium.

|February 20, 2002

Abstract:

The identification of endothelial progenitor cells (EPCs) in the adult human has forced us to reconsider how new blood vessels grow in physiological and pathological conditions in the adult human. An important question in angiogenesis research is to what extent these progenitors functionally contribute to revascularization of ischemic tissues and and to what extent they can be used for therapeutic angiogenic cell transplantation. Even more challenging is the concept that hematopoietic and other bone-marrow-derived stem cells might be recruited in the context of ischemia to induce neovessel formation. This review discusses some of the recent insights and outstanding questions on EPCs, both from a biological and therapeutic perspective.

Related Experiment Videos

Vascular progenitors: from biology to treatment

Related Concept Videos

Renal Vdr deletion drives urinary calcium loss with intestinal and skeletal compensatory responses.

Metabolic flexibility secures skeletal progenitor function upon reduced glycolysis driven by PFKFB3 loss.

Defining the vascular niche of human adipose tissue across metabolic states.

Changes in bone characteristics precede serum mineral deterioration in a mouse model of early stage chronic kidney disease.

Prdm16 Amplifies Notch Signaling and Suppresses Venous Lineage Specification to Prevent Arteriovenous Malformations During Vascular Development.

A novel model to study the impact of gender-affirming therapy on bone in young male mice.

Stereotactic Body Radiotherapy for Cardiac Arrhythmias: Current Evidence and Clinical Boundaries.

Artificial Intelligence in Cardiovascular Imaging and Risk Stratification: From Algorithmic Discovery to Meaningful Clinical Implication.

Electrocardiographic abnormalities secondary to acute central nervous system injury.

Cardiac implantable electronic device infections: Emerging paradigms in precision prevention and personalized management.

Smartwatch and wearable detection of atrial fibrillation: Current evidence and clinical implications.

Racial and ethnic disparities in percutaneous coronary intervention: contemporary evidence and pathways to equity.

Bovine umbilical cord tissue‑derived MSCs and its conditioned medium promote the healing of excisional wound in rats.

Injection Mapping and Dose Escalation For Botulinum Toxin Treatment on the Lower Face: A Randomized, Double-blind Clinical Trial.

Tldi1 deficiency mediates Tlde1 self-toxic effect to regulate the adaptability of Salmonella Typhimurium infection and host immune response in mice.

[Outcomes of 3D culture of human lacrimal gland cells (pilot study)].

Targeting TGF-β to Attenuate Ischemia-Reperfusion Associated Muscle Fibrosis and Enhance Regeneration: A Preclinical Study.

Helical Cartilage Inversion and V-Y Advancement Flap for Type IIB Constricted Ear Correction.

Related Experiment Videos

Vascular progenitors: from biology to treatment

Abstract:

Related Concept Videos

Related Articles