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Activity-based diary for Parkinson's disease.

Johan Marinus1, Martine Visser, Anne M Stiggelbout

  • 1Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Clinical Neuropharmacology
|February 20, 2002
PubMed
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This study developed a Parkinson's disease diary to assess daily activity difficulties, replacing traditional "on"- and "off"-time. The diary accurately reflects motor fluctuations and symptom severity in patients.

Area of Science:

  • Neurology
  • Clinical Assessment
  • Patient-Reported Outcomes

Background:

  • Traditional "on" and "off" time assessment in Parkinson's disease (PD) can be burdensome.
  • A need exists for patient-centered tools to capture daily functional status and motor fluctuations.

Purpose of the Study:

  • To develop and evaluate the clinimetric properties of a novel Parkinson's disease diary.
  • To assess the diary's ability to measure patient-perceived difficulties in daily activities as a proxy for "on" and "off" states.

Main Methods:

  • 84 Parkinson's disease patients completed a diary over 2-3 periods of 5 days, recording 5 items across 11 time periods daily.
  • Diary data was analyzed for clinimetric properties, including internal consistency, reproducibility, and construct validity.

Related Experiment Videos

  • The diary was optimized to a 3-day version assessing walking, transfers, manual activities, dyskinesias, and sleep.

    • Main Results:

    • The optimized 3-day diary effectively captured patient-perceived disability and motor fluctuations.
    • Sumscores of key items accurately predicted "on"/"off" status in 93% of cases, simplifying assessment.
    • The diary demonstrated good internal consistency, reproducibility, and adequate construct validity.

    Conclusions:

    • The developed Parkinson's disease diary is a valid and reliable tool for assessing daily functional difficulties.
    • This diary offers a patient-centered approach to understanding symptom severity and motor fluctuations in Parkinson's disease.
    • It provides a practical alternative for evaluating "off"-periods and disease variability.