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Related Experiment Videos

Superselective mesenteric embolization with microcoils in a porcine model.

Anthony C Chin1, Marc A Singer, Michael Mihalov

  • 1Department of Surgery, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

Diseases of the Colon and Rectum
|February 20, 2002
PubMed
Summary

Superselective arterial embolotherapy using platinum microcoils showed minimal bowel changes and no clinical complications in pigs. This transcatheter arterial embolization technique appears safe for treating gastrointestinal hemorrhage.

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Area of Science:

  • Interventional Radiology
  • Gastroenterology
  • Vascular Surgery

Background:

  • Superselective arterial embolotherapy with platinum microcoils is used for gastrointestinal hemorrhage.
  • Data on ischemic complications in small and large bowel following this procedure is limited.

Purpose of the Study:

  • To evaluate ischemic complications in the bowel after superselective arterial embolotherapy with platinum microcoils.
  • To assess gross and histologic changes in postembolectomy bowel specimens in a porcine model.

Main Methods:

  • Platinum microcoils were deployed into mesenteric arteries of nine pigs.
  • Animals were observed for 2 days, 1 month, or 3 months post-embolization.
  • Intestines were examined grossly and histologically for ischemic changes.

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Main Results:

  • 54 microcoils were deployed without clinical complications; all pigs gained weight.
  • No gross evidence of acute or chronic ischemia was observed.
  • Histologic examination showed minimal superficial villous tip necrosis, likely artifactual, with no other signs of ischemic injury.

Conclusions:

  • Superselective arterial embolotherapy with microcoils resulted in minimal bowel changes and no significant clinical consequences in pigs.
  • Transcatheter arterial embolization is a potentially safe and applicable method for controlling massive lower gastrointestinal hemorrhage.