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Stabilization of pharmaceuticals to oxidative degradation
Kenneth C Waterman1, Roger C Adami, Karen M Alsante
1Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. ken_waterman@groton.pfizer.com
Pharmaceutical Development and Technology
|February 21, 2002
Abstract:
A guide for stabilization of pharmaceuticals to oxidation is presented. Literature is presented with an attempt to be a ready source for data and recommendations for formulators. Liquid and solid dosage forms are discussed with options including formulation changes, additives, and packaging documented. In particular, selection of and methods for use of antioxidants are discussed including recommended levels.