Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sequential experimentation in product development. I.

Anil Menon1, Sibu Chakrabarti, Nadhamuni Nerella

  • 1Sanofi-Synthelabo, 9 Great Valley Parkway, Malvern, PA 19355, USA. anil.menon@sanofi-synthelabo.com

Pharmaceutical Development and Technology
|February 21, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disability-related barriers to dental care among older Canadian adults: the role of sex as an effect modifier.

Frontiers in oral health·2026
Same author

The Association Between Exclusive Breastfeeding, Bottle-Feeding, and Oral Rothia on Early Childhood Caries.

Pediatric dentistry·2026
Same author

A National Review of the Interim Canada Dental Benefit: Analyzing the Uptake Among Uninsured Children Under 12.

Journal of public health dentistry·2026
Same author

Mixed-Method Evaluation of the Impact of a "Healthcare Exploration Through Patient Care" Course on Undergraduate Students.

Medical science educator·2026
Same author

The politics of integrating health systems and public programs: a review of political headwinds, tailwinds, and policy maker recommendations.

European journal of public health·2026
Same author

Oral Health Professionals' Views on the Interim Canada Dental Benefit in Manitoba, Canada.

Journal of public health dentistry·2026
Same journal

<i>Camellia sinensis</i> Silver Nanoparticles Inhibit Proliferation and Induce PARP-Dependent Apoptosis in A549 Cells: Formulation, Characterization, and Biological Evaluation.

Pharmaceutical development and technology·2026
Same journal

Enhanced solubility and bioavailability of zanubrutinib nanocrystals: Physicochemical and Pharmacokinetic evaluation.

Pharmaceutical development and technology·2026
Same journal

Intradermal delivery of lidocaine hydrochloride using dissolving microneedles: <i>in vitro</i> dermatokinetic test and <i>in vivo</i> anesthetic activity assessment.

Pharmaceutical development and technology·2026
Same journal

Quality by design-guided development of silica-enabled lipid hybrid nanoparticles for enhanced olaparib dissolution.

Pharmaceutical development and technology·2026
Same journal

Surface engineering of nanocarriers with polymer coatings: materials, strategies, functional outcomes, and clinical translation.

Pharmaceutical development and technology·2026
Same journal

Compression equations in pharmaceutical tableting: from classical compaction models to data-driven and mechanistic approaches.

Pharmaceutical development and technology·2026
See all related articles

Sequential experimentation, a recursive learning process, improves product development. A fluid-bed granulation study demonstrated success using technical knowledge, factorial designs, and graphical analysis for better experimental cycles.

Area of Science:

  • Chemical Engineering
  • Process Development

Background:

  • Scientific investigations are iterative, relying on sequential experiments.
  • Evaluating prior results informs the design of subsequent experimental cycles.

Purpose of the Study:

  • To highlight the importance of sequential experimentation in product development.
  • To illustrate a sequential approach using a fluid-bed granulation case study.

Main Methods:

  • Utilized technical knowledge for experimental design.
  • Employed a sequence of factorial designs.
  • Applied graphical data analysis for result interpretation.

Main Results:

  • Achieved acceptable solutions for fluid-bed granulation.

Related Experiment Videos

  • Demonstrated the effectiveness of the iterative experimental approach.
  • Successfully integrated technical expertise with systematic design and analysis.

    • Conclusions:

    • Sequential experimentation is a valuable strategy for efficient product development.
    • The combination of technical knowledge, factorial design, and graphical analysis leads to successful outcomes.
    • Iterative learning enhances the design and prediction of experimental cycles.