Related Experiment Video
Updated: Aug 9, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
Mechanisms of traumatic brain injury: biomechanical, structural and cellular considerations
1University of Michigan School of Nursing, Ann Arbor, USA.
Abstract:
Traumatic brain injury (TBI) is a public health problem of great concern, because it affects more than 2 million individuals each year. TBI occurs as a result of motor vehicle crashes, falls, and sports-related events. Biomechanical mechanisms occurring at the time of the injury initiate primary and secondary injuries that evolve over several days. In this article the relationship between an blunt injury event and the subsequent damage produced is addressed. Mechanisms of brain injury from biomechanics to cellular pathobiology are presented. Primary and secondary injuries are differentiated, and specific focal and diffuse clinical syndromes are described. Cellular mechanisms responsible for injury are also addressed, because they provide the unifying concepts across the many clinical syndromes so often discussed separately in reviews of traumatic brain injury.
More Related Videos
09:29Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
Published on: July 10, 2019
09:49Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Related Concept Videos
Hemorrhagic Stroke ll: Pathophysiology
Traumatic Brain Injury l: Introduction
Spinal Cord Injury ll: Pathophysiology
Cerebral Edema ll: Pathophysiology
Secondary Spinal Cord Injury llI: Pathophysiology