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Related Experiment Videos

The study on a PVC membrane electrode for gemfibrozil.

Xu Fen1, Li-Xian Sun, Naoki Matsuda

  • 1Dalian Institute of Chemical Physics, Chinese Academy of Sciences, People's Republic of China.

Biological & Pharmaceutical Bulletin
|February 21, 2002
PubMed
Summary

A new poly(vinyl chloride) (PVC) membrane electrode was developed for gemfibrozil determination. This ion-selective electrode shows a Nernstian response and is effective for analyzing gemfibrozil in pharmaceutical preparations.

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Area of Science:

  • Analytical Chemistry
  • Electrochemistry
  • Materials Science

Background:

  • Gemfibrozil is a widely used lipid-regulating drug.
  • Accurate determination of gemfibrozil in pharmaceutical formulations is crucial for quality control.
  • Ion-selective electrodes offer a sensitive and selective method for drug analysis.

Purpose of the Study:

  • To develop and optimize a novel poly(vinyl chloride) (PVC) membrane electrode for the potentiometric determination of gemfibrozil.
  • To investigate the electrode's performance characteristics, including response range, slope, and limit of detection.
  • To evaluate the electrode's applicability in the analysis of gemfibrozil in real pharmaceutical samples.

Main Methods:

  • Preparation of a PVC membrane electrode incorporating ion-pair complexes of gemfibrozil with hexadecyltrioctyl ammonium iodide (HTOA).

Related Experiment Videos

  • Optimization of membrane composition using the sequential level elimination method for orthogonal experimental design.
  • Potentiometric measurements were conducted using a Na2B4O7-Na2CO3 buffer at pH 11.0.

    • Main Results:

    • The optimized electrode exhibited a Nernstian response over a concentration range of 2.5 x 10(-5) to 0.1 mol/l with a slope of 55.3 mV/decade.
    • The limit of detection was determined to be 7.1 x 10(-6) mol/l.
    • The electrode's response remained stable across a pH range of 10.0-12.3 and demonstrated satisfactory performance in pharmaceutical preparations.

    Conclusions:

    • A robust and sensitive PVC membrane electrode for gemfibrozil determination has been successfully developed.
    • The optimized electrode offers a reliable method for the quantitative analysis of gemfibrozil in pharmaceutical products.
    • The developed potentiometric sensor provides a valuable tool for pharmaceutical quality control and drug analysis.