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Correlation between serum magnesium and blood cyclosporine A concentrations in renal transplant recipients

V Thakur1, R Kumar, I K Dhawan

  • 1Department of Laboratory Medicine, Batra Hospital and Medical Research Centre, New Delhi, India. vthakur57@hotmail.com

Annals of Clinical Biochemistry
|February 21, 2002
PubMed

Insights

Renal transplant patients on cyclosporine therapy show low serum magnesium levels, increasing risks for hypertension and cardiac death. Regular monitoring of magnesium is crucial for these patients.

Area of Science:

  • Nephrology
  • Pharmacology
  • Clinical Chemistry

Background:

  • Renal transplant recipients on cyclosporine therapy exhibit low serum magnesium.
  • Low magnesium is a risk factor for hypertension and cardiac death.
  • No prior studies from the Indian subcontinent investigated magnesium and cyclosporine A levels.

Purpose of the Study:

  • To investigate the relationship between total serum magnesium and cyclosporine A concentration in renal transplant recipients.
  • To assess magnesium levels in Indian patients undergoing renal transplantation.

Main Methods:

  • Measured blood cyclosporine A and total serum magnesium in 31 post-renal transplant patients.
  • Included 16 chronic renal failure patients without transplants as controls.

Main Results:

  • Post-transplant patients had significantly lower mean serum magnesium (0.64+/-0.11 mmol/L) compared to controls (1.0+/-0.16 mmol/L).
  • An inverse correlation (r = -0.532) was observed between serum magnesium and blood cyclosporine A concentration.
  • Cyclosporine-treated patients exhibited higher systolic and diastolic blood pressures.

Conclusions:

  • Serum magnesium levels should be regularly monitored in patients receiving cyclosporine A.
  • Hypomagnesemia is associated with cyclosporine therapy in renal transplant patients.
Abstract

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