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Related Experiment Videos

Quetiapine for tic disorder: a case report.

T Chan-Ob1, N Kuntawongse, V Boonyanaruthee

  • 1Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|February 21, 2002
PubMed
Summary

Quetiapine effectively reduced tics in a patient with tic disorder, demonstrating fewer extrapyramidal side effects (EPS). Further trials are needed to establish quetiapine as a first-line tic disorder treatment.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Child Psychiatry

Background:

  • Tic disorders affect approximately 20% of children, with limited treatment options.
  • Established antipsychotics like haloperidol and pimozide are effective but associated with significant extrapyramidal side effects (EPS).
  • Risperidone shows efficacy but can also cause EPS, necessitating exploration of newer agents.

Observation:

  • A case report details a 19-year-old female with tic disorder previously treated with haloperidol and risperidone.
  • The patient experienced acute dystonia and oculogyric crisis, along with persistent symptoms and EPS.
  • Quetiapine was initiated at 50 mg/d without adjunctive benzhexol HCl, with dosage titration based on symptom severity.

Findings:

  • Quetiapine treatment led to tic improvement within the first week and complete disappearance for three weeks at 150 mg/d.

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  • Tics recurred at a lower frequency (20%) necessitating a dose increase to 200 mg/d.
  • At 200 mg/d, quetiapine reportedly resolved the patient's tics with minimal reported EPS.

    • Implications:

    • Quetiapine demonstrates potential efficacy and a favorable side effect profile for treating tic disorders.
    • The findings suggest quetiapine may be a viable alternative for patients experiencing EPS with other antipsychotics.
    • Controlled clinical trials are essential to validate these findings and determine quetiapine's role in tic disorder management.