Related Experiment Video

Updated: Aug 11, 2026

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
09:40

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells

Published on: June 20, 2018

Myelofibrosis in children with chronic renal insufficiency

N Schlackman, A A Green, J L Naiman

    The Journal of Pediatrics
    |November 1, 1975
    PubMed

    Insights

    Anemia in chronic renal failure may stem from myelofibrosis, a condition where bone marrow is replaced by fibrous tissue. This bone marrow scarring can impact treatment tolerance, especially after kidney transplants.

    Area of Science:

    • Nephrology
    • Hematology
    • Pathology

    Background:

    • Chronic renal failure (CRF) is associated with anemia and osteodystrophy.
    • Bone marrow examination is crucial for diagnosing hematological disorders.

    Purpose of the Study:

    • To investigate the cause of splenomegaly and anemia in a boy with CRF.
    • To examine bone marrow changes in children with CRF.

    Main Methods:

    • Bone marrow aspiration and biopsy were performed.
    • Histopathological examination of biopsied bone marrow.

    Main Results:

    • Bone marrow aspirates yielded "dry taps" in affected children.
    • Biopsied bone marrow showed replacement by fibrous tissue, indicating myelofibrosis.
    • Splenomegaly was observed in conjunction with these bone marrow changes.

    Conclusions:

    • Anemia in CRF may be partly caused by myelofibrosis.
    • Myelofibrosis reduces functional bone marrow capacity.
    • Reduced bone marrow function may affect immunosuppressive therapy tolerance in renal transplant recipients.

    More Related Videos

    Refined Murine Model of Idiopathic Pulmonary Fibrosis07:51

    Refined Murine Model of Idiopathic Pulmonary Fibrosis

    Published on: June 17, 2025

    Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury07:02

    Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

    Published on: February 10, 2026

    Related Concept Videos

    Dialysis01:27

    Dialysis

    Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
    Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
    Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

    Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

    Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
    Acute Kidney Injury I: Introduction01:22

    Acute Kidney Injury I: Introduction

    Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
    Acute Kidney Injury III: Clinical Manifestations01:29

    Acute Kidney Injury III: Clinical Manifestations

    Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...