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Updated: Jul 21, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
Published on: November 2, 2011
The formation of polymer vesicles or "peptosomes" by polybutadiene-block-poly(L-glutamate)s in dilute aqueous
Hildegard Kukula1, Helmut Schlaad, Markus Antonietti
1Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Abteilung Kolloidchemie, Am Mühlenberg 1, D-14476 Golm, Germany.
Abstract:
Polybutadiene-block-poly(L-glutamate) copolymers were made by anionic polymerization and subsequent ring-opening polymerization of N-carboxyanhydrides and were characterized by NMR, IR, SEC, and circular dichroism. These polymers, when appropriately designed, form so-called "polymersomes" or "peptosomes", vesicles composed of modified protein units. The size and structure of the vesicles are determined by dynamic light scattering, small-angle neutron scattering, and freeze-fracture electron microscopy. It is also shown that the size of the peptosomes does not depend on the pH; that is, the solvating peptide units can perform a helix-coil transition without serious changes of the vesicle morphology.

