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[Effects of synthetic interleukin-1 blockers on uveitis in rats]
1Department of Ophthalmology, Tong Ren Hospital, The Capital University of Medical Sciences, Beijing 100730, China.
Objective:
To investigate the therapeutic action of synthetic interleukin-1 blockers on uveitis in rats.
Method:
Experiments were performed on 18 Spraque-Dawley rats (36 eyes), and the retinal interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) were quantified by an enzyme-linked immunoabsorbent assay (ELISA) before and after the rats with uveitis treated by synthetic interleukin-1 blockers.
Result:
The retinal IL-1 beta and TNF-alpha in rats with uveitis treated by synthetic IL-1 blockers (CK-138, 139) were significantly decreased than those treated by contrasting design.
Conclusion:
Synthetic IL-1 blockers (CK-138, 139) are effective in treatment of IL-1 alpha induced uveitis in the rat.