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[The protective effect of ligustrazine on optic nerve axons in rabbit eyes with continuous elevated IOP]
1Central laboratory, Department of Ophthalmology, Affiliated Hospital of Weifang Medical College, Shandong 261031, China.
Objective:
To investigate the effects of ligustrazine on optic nerve axons in rabbit eyes with continuous elevated intraocular pressure (IOP).
Method:
Thirty-six NZ rabbits with continuous elevated IOP induced by injection of alpha-chymotrypsin into anterior chamber were divided into two groups by randomization: treatment and control group. Ten mg/kg ligustrazine injected into the treatment group every day for 3 weeks began on the 7(th) day after IOP elevated continuously. The changes of conjunctival microcirculation and optic nerve axonal ultrastructure were observed at different time points.
Results:
The destruction of conjunctival microcirculation and axonal ultrastructure was milder in treatment group than that in the control group. In addition, the total number of axons and the percentage of axons in optic nerve area were higher, whereas the axonal diameter was smaller in the treatment group.
Conclusion:
It is suggested that ligustrazine protect optic nerve axons from more damage induced by elevated IOP through improving ocular microcirculation.