A multilateral effort to develop DNA vaccines against falciparum malaria

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CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum
09:25

CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum

Published on: September 18, 2018

Sanjai Kumar1, Judith E Epstein, Thomas L Richie

  • 1Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA. kumars@nmrc.navy.mil

Trends in Parasitology
|February 21, 2002
PubMed

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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...