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Updated: Aug 10, 2026

Enzyme-linked Immunospot Assay (ELISPOT): Quantification of Th-1 Cellular Immune Responses Against Microbial Antigens
Published on: November 23, 2010
Selective T-cell recognition of the N-terminal peptide of GroES in tuberculosis
Boosbun Chua-Intra1, Robert J Wilkinson, Juraj Ivanyi
1MRC Clinical Sciences Centre, Hammersmith Hospital, London W12 0NN, United Kingdom.
Abstract:
Peptides derived from the whole sequence of mycobacterial GroES heat shock proteins were tested for the ability to induce the proliferation of blood mononuclear cells from tuberculosis patients and sensitized healthy subjects. The response to the N-terminal peptide (residues 1 to 16) was found to be more frequent and stronger in tuberculosis patients. This finding is exceptional, considering that recognition of all other GroES peptides by patients was either diminished or not different from that of controls.
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