Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adenoviral gene therapy.

Stephan A Vorburger1, Kelly K Hunt

  • 1Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

The Oncologist
|February 21, 2002
PubMed
Summary

Gene therapy trials show promise, with adenoviruses being key delivery vectors. Engineered adenoviruses now target tumors selectively, advancing clinical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness and Safety of Magseed-localization for Excision of Breast Lesions: A Prospective, Phase IV Trial.

Annals of surgery open : perspectives of surgical history, education, and clinical approaches·2021
Same author

Breast Sarcomas, Phyllodes Tumors, and Desmoid Tumors: Epidemiology, Diagnosis, Staging, and Histology-Specific Management Considerations.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting·2021
Same author

Five-Year Longitudinal Analysis of Patient-Reported Outcomes and Cosmesis in a Randomized Trial of Conventionally Fractionated Versus Hypofractionated Whole-Breast Irradiation.

International journal of radiation oncology, biology, physics·2021
Same author

LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers.

Oncogenesis·2021
Same author

Prospective Study of Pain Outcomes Associated With Breast Surgery in Women With Nonhereditary Breast Cancer.

Annals of surgery·2021
Same author

Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or <i>BRCA1</i> Alteration.

Cancers·2021

Area of Science:

  • Biomedical research
  • Molecular biology
  • Oncology

Background:

  • Over 500 gene therapy protocols were approved by May 2001, but few reached Phase III trials.
  • Adenoviruses are frequently used vectors for gene delivery in human cells.
  • Despite progress, adenoviral vectors have limitations in gene therapy.

Purpose of the Study:

  • To review the progress and challenges of adenoviral vectors in gene therapy.
  • To highlight the development of engineered adenoviruses for targeted tumor delivery.
  • To discuss the application of these advanced vectors in clinical settings.

Main Methods:

  • Review of approved gene therapy protocols and clinical trial phases.
  • Analysis of adenoviral vector applications and advancements.
  • Examination of engineered adenoviruses for tumor-specific targeting.

Main Results:

  • Only five out of 532 gene therapy protocols had reached Phase III trials by May 2001.
  • Adenoviral vectors have shown significant progress but still face challenges.
  • Engineered adenoviruses demonstrate selective tumor targeting under controlled promoters.

Conclusions:

  • Adenoviral vectors are crucial for gene delivery, with ongoing improvements.
  • Engineered adenoviruses offer enhanced specificity for tumor targeting in gene therapy.
  • Advancements in adenoviral vector technology are paving the way for more effective cancer treatments.

Related Experiment Videos