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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Published on: September 9, 2012

Coagulopathy as a result of factor V inhibitor after exposure to bovine topical thrombin

David G Neschis1, Meyer R Heyman, Vasana Cheanvechai

  • 1Division of Vascular Surgery, University of Maryland School of Medicine, Baltimore, USA. dneschis@smail.umaryland.edu

Journal of Vascular Surgery
|February 21, 2002
PubMed

We describe a case of severe coagulopathy after mesenteric revascularization. Laboratory investigation results revealed the presence of plasma inhibitors of factor V believed to result from exposure to bovine thrombin used for intraoperative hemostasis. Vascular and cardiothoracic surgeons commonly use topical thrombin for surgical hemostasis, and many patients undergo multiple exposure. More patients likely have factor V inhibitors develop than has previously been realized, and this may account for some otherwise unexplained postoperative coagulation disorders. This report may alert surgeons to coagulation disturbances that can result from exposure to bovine thrombin and provide guidelines for diagnosis and management.

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