Preliminary X-Ray Investigations Into NSAID-Binding to Cyclooxygenase-1

The prostaglandin H synthase structure reveals a fold similar to those of other heme peroxidases, but within this fold a second active site has evolved which catalyzes the cyclooxygenase reaction. The protein has also acquired two additional domains: a membrane-binding motif that mediates the protein's monotopic attachment to the membrane, and an epidermal growth factor-like module which is found just before the membrane-binding motif and is located in the dinner interface.