Related Experiment Videos
Oxygen consumption after hypothermic cardiopulmonary bypass: the effect of continuing a propofol infusion
Stewart E Milne1, Kenneth S James, Susan Nimmo
1Department of Anaesthesia, Glasgow Royal Infirmary, Glasgow, United Kingdom. smilne@umich.edu
Objective:
To evaluate the effect of a fixed rate of infusion of propofol on total body oxygen consumption during the postoperative rewarming phase after cardiopulmonary bypass.
Design:
Prospective, randomized, controlled study.
Setting:
Cardiac intensive care unit, university hospital.
Participants:
Twenty-four male and female patients undergoing elective first-time coronary artery bypass graft surgery.
Interventions:
Total body oxygen consumption was measured using a pulmonary artery catheter and thermodilution during postoperative rewarming. Twelve patients had propofol infused at 2 mg/kg/h for 4 hours or until rewarmed.
Measurements And Main Results:
Total body oxygen consumption was reduced in the propofol group compared with the control group. Oxygen consumption was a median of 30.0 mL/min/m(2) less in the patients receiving propofol (p = 0.01). One patient receiving propofol shivered compared with 4 in the control group (p = 0.14).
Conclusion:
Administration of propofol during postoperative rewarming reduces total body oxygen consumption and may reduce shivering.