Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heparin-bonded cardiopulmonary bypass circuits reduce cognitive dysfunction.

Eric J Heyer1, Kevin S Lee, Heather E Manspeizer

  • 1Departments of Anesthesiology, Surgery, and Neurology, College of Physicians and Surgeons of Columbia University, and Columbia--Presbyterian Medical Center, New York, NY 10032, USA. ejh3@columbia.edu

Journal of Cardiothoracic and Vascular Anesthesia
|February 21, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serial drilling technique for sequential subtrochanteric femur fracture fixation in pediatric osteopetrosis: a technical report.

OTA international : the open access journal of orthopaedic trauma·2026
Same author

Multiplexed Retinoic Acid Signal Reporters for In Vivo and In Vitro Use.

Genesis (New York, N.Y. : 2000)·2026
Same author

Identification and Documentation of Patient Social Risk Factors in the Prehospital Setting: A Pilot Implementation.

Prehospital emergency care·2026
Same author

Assessing and strengthening community-based coastal governance.

Conservation biology : the journal of the Society for Conservation Biology·2026
Same author

Impact of dipeptidyl peptidase I and neutrophil serine proteases on neutrophil functional responses.

Frontiers in pharmacology·2026
Same author

Sustainable gold leaching from waste printed circuit boards using biogenic thiosulphate produced by Acidithiobacillus thiooxidans.

Bioresource technology·2026

Heparin-bonded cardiopulmonary bypass (HB-CPB) circuits reduce postoperative cognitive dysfunction in cardiac surgery patients compared to nonheparin-bonded (NH-CPB) circuits. This improvement in cognitive function was observed despite no significant difference in inflammatory markers or coagulation activation.

Area of Science:

  • Cardiovascular Surgery
  • Neuroscience
  • Inflammation Research

Background:

  • Cardiopulmonary bypass (CPB) is associated with a risk of cerebral dysfunction.
  • The use of heparin-bonded (HB-CPB) circuits aims to mitigate the inflammatory response during CPB.

Purpose of the Study:

  • To compare the incidence of cerebral dysfunction between HB-CPB and nonheparin-bonded (NH-CPB) circuits.
  • To correlate neuropsychometric findings with systemic inflammatory response markers.

Main Methods:

  • Prospective, randomized, blinded clinical trial involving 61 elective cardiac surgery patients.
  • Neuropsychometric testing at baseline, postoperative day 5, and postoperative week 6.
  • Measurement of inflammatory markers (cytokines, C3a) and coagulation markers (thrombin-antithrombin complex).

Related Experiment Videos

Main Results:

  • Patients using HB-CPB showed significantly better performance on specific neuropsychometric tests at 5 days and 6 weeks post-surgery.
  • Event-rate analysis indicated less cognitive dysfunction in the HB-CPB group at 5 days (p < 0.05).
  • Complement activation (C3a) was higher in the NH-CPB group, while coagulation activation (TAT) was higher in the HB-CPB group postoperatively.

Conclusions:

  • Heparin-bonded CPB circuits are associated with reduced postoperative cognitive dysfunction in cardiac surgery patients.
  • The observed cognitive benefits did not directly correlate with reduced intraoperative complement activation or postoperative coagulation activation.