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Related Experiment Videos

SS-penogram: a new diagnostic test for erectile dysfunction.

Hyung Ki Choi1, Yeong Jin Choi, Young Deuk Choi

  • 1Department of Urology and Institute of Andrology,Yonsei University College of Medicine, P.O. Box 1217, Seoul 135-720, Korea. ssclinic@yumc.yonsei.ac.kr

Yonsei Medical Journal
|February 21, 2002
PubMed
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Sildenafil (Viagra) improved erectile function in 76% of men with erectile dysfunction (ED) as measured by the novel SS-Penogram. This objective method assesses erectile status during sexual and pharmacological stimulation, aiding ED treatment evaluation.

Area of Science:

  • Urology
  • Radiology
  • Pharmacology

Background:

  • Clinical reports on Sildenafil (Viagra) for erectile dysfunction (ED) often lack objective data.
  • There is a need for validated, non-invasive methods to assess ED and treatment efficacy.

Purpose of the Study:

  • To objectively evaluate the efficacy of Sildenafil in patients with ED using a newly developed radioisotope-based method.
  • To assess the diagnostic capability of the SS-Penogram in quantifying erectile response.

Main Methods:

  • Developed and utilized the SS-Penogram, a non-invasive radioisotope (RI) method, on 104 patients with ED.
  • Administered Sildenafil (25-100 mg) and performed serial SS-Penograms to measure changes in erectile response.
  • Classified penogram results into Types I (normal), II-A (impossible), II-B (unstable), and II-C (delayed) for analysis.

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Main Results:

  • Sildenafil administration improved erectile function, with 76% (79/104) showing augmented erectile capabilities.
  • Excellent response (>50% RI area increase) was observed in 53.9% of patients, good response (20-50% increase) in 22.1%, and borderline in 14.4%.
  • A non-response rate of 9.6% (10/104) was noted, with efficacy not correlating with patient age (p=0.198).

Conclusions:

  • The SS-Penogram provides an objective and physiological assessment of erectile status under sexual and pharmacological stimulation.
  • Sildenafil demonstrates significant therapeutic efficacy in a majority of men with ED, as objectively measured by the SS-Penogram.
  • The SS-Penogram is a valuable tool for evaluating ED treatment efficacy in clinical trials, with further study needed for non-responders.