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Enhancing fluidity of concentrated antacid suspensions
Journal of Pharmaceutical Sciences
|October 1, 1975
Abstract:
Highly concentrated antacid suspension can by fluidized by adding a colloidal polyelectrolyte to alter the charge on antacid particles from positive to negative. A deflocculated state is assumed to exist in such preparations, as supported by electrophoretic and viscometric analyses. When viscosity is directly correlated with the zota-potential, viscometry becomes particularly useful in confirming that the suspension has been maximally fluidized.