Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A train of thoughts on gene mapping.

J Hoh1, J Ott

  • 1Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

Theoretical Population Biology
|February 22, 2002
PubMed
Summary

Complex traits result from multiple interacting genes. This study explores advanced methods for analyzing genetic markers simultaneously, improving disease gene mapping and statistical modeling for complex traits.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Premature ovarian insufficiency and autoimmune profiles: a prospective case-control study.

Climacteric : the journal of the International Menopause Society·2023
Same author

Measurement of the top quark mass using a profile likelihood approach with the lepton + jets final states in proton-proton collisions at <math></math>.

The European physical journal. C, Particles and fields·2023
Same author

Observation of τ Lepton Pair Production in Ultraperipheral Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2023
Same author

Search for Exotic Higgs Boson Decays H→AA→4γ with Events Containing Two Merged Diphotons in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2023
Same author

Observation of Same-Sign WW Production from Double Parton Scattering in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2023
Same author

Measurements of jet multiplicity and jet transverse momentum in multijet events in proton-proton collisions at <math></math>.

The European physical journal. C, Particles and fields·2023

Area of Science:

  • Genetics
  • Biostatistics
  • Complex Trait Analysis

Background:

  • Complex traits arise from the interplay of numerous genes.
  • Traditional single-locus association studies are limited in scope.
  • Simultaneous analysis of multiple genetic markers offers a more comprehensive approach.

Purpose of the Study:

  • To introduce alternative marker selection strategies for complex traits.
  • To discuss analytical tools for disease gene mapping.
  • To address statistical modeling for gene-gene interactions.

Main Methods:

  • Review and propose alternative marker selection techniques.
  • Discuss simultaneous analysis of genetic markers.
  • Evaluate statistical modeling for main and interaction effects.

Main Results:

  • Identified alternative approaches for influential marker selection.
  • Highlighted challenges in disease gene mapping and statistical modeling.
  • Emphasized the benefits of simultaneous marker analysis over traditional methods.

Conclusions:

  • Advanced analytical methods are crucial for understanding complex traits.
  • Simultaneous marker analysis and robust statistical modeling improve disease gene mapping.
  • Further development of analytical tools is needed for complex trait genetics.

Related Experiment Videos