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Updated: Oct 2, 2026
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis and biological evaluation of a new furo[2,3-h]quinolin-2(1H)-one
Adriana Chilin1, Christine Marzano, Adriano Guiotto
1Department of Pharmaceutical Sciences, University of Padua, Via Francesco Marzolo 5, I-35131 Padova, Italy.
Abstract:
A new furoquinolinone derivative, namely 4-hydroxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one (HOFQ), was synthesized and its biological activity studied. By UVA activation, HOFQ induced strong antiproliferative effects in Ehrlich ascite cells, which lost their ability to transmit the tumor by transplantation. HOFQ exhibited poor genotoxicity and absence of skin phototoxicity. Actually, HOFQ sensitization forms DNA-protein cross-linkages but not interstrands cross-links. Therefore, HOFQ appears to be a new promising drug for PUVA photochemotherapy and photopheresis.
