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Amphidinolide W, a new 12-membered macrolide from dinoflagellate Amphidinium sp
Kazutaka Shimbo1, Masashi Tsuda, Naoko Izui
1Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
The Journal of Organic Chemistry
|February 22, 2002
Abstract:
A new cytotoxic 12-membered macrolide, amphidinolide W (1), has been isolated from a marine dinoflagellate Amphidinium sp., and the structure was elucidated by spectroscopic data including (13)C-(13)C INADEQUATE correlations for its (13)C-enriched sample. The absolute stereochemistry of 1 was assigned by combination of J-based configuration analysis and modified Mosher method. Amphidinolide W (1) is the first macrolide without an exomethylene unit among all amphidinolides obtained so far.