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Related Experiment Videos

Delayed maternity and risk at delivery.

Paola Astolfi1, Laura A Zonta

  • 1Department of Genetics and Microbiology, University of Pavia, Italy. astolfi@ipvgen.unipv.it

Paediatric and Perinatal Epidemiology
|February 22, 2002
PubMed
Summary

Advanced maternal age increases the risk of adverse pregnancy outcomes, including stillbirth, preterm birth, and low birthweight. Factors like education and parity significantly modify this risk, with young, highly educated mothers having the lowest risk.

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Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Health
  • Perinatal Epidemiology

Background:

  • Maternal age is a critical factor influencing pregnancy outcomes.
  • Increasing trends in delayed childbearing necessitate understanding associated risks.

Purpose of the Study:

  • To evaluate the impact of maternal age on the risk of unfavorable pregnancy outcomes.
  • To analyze how maternal education and parity modify age-related risks.

Main Methods:

  • Retrospective cohort study analyzing data from 1990-1994 in Italy.
  • Inclusion of over 1.3 million first-born and 950,000 second-born infants.
  • Assessment of stillbirth, preterm birth, and low birthweight risks, evaluated globally and individually.

Main Results:

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  • Mothers aged 35 years and older face significantly increased risks for adverse pregnancy outcomes.
  • Primiparous mothers aged 35+ with low education exhibited a threefold higher global risk compared to young, highly educated multiparous mothers.
  • Global risk increased annually from age 26, with parity and education acting as significant modifiers.

Conclusions:

  • Advanced maternal age is a substantial risk factor for adverse pregnancy outcomes.
  • Maternal education and parity play crucial roles in modulating the risks associated with older maternal age.
  • The trend towards later childbearing suggests a growing proportion of women may experience these elevated risks in the future.