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Abdominal wall defects in Denmark, 1970-89.

M Bugge1, N V Holm

  • 1Wilhelm Johannsen Centre for Functional Genome Research, Department of Medical Genetics, Institute of Biochemistry and Genetics, University of Copenhagen, Denmark. MB@IMBG.ku.dk

Paediatric and Perinatal Epidemiology
|February 22, 2002
PubMed
Summary

Gastroschisis rates increased significantly in recent decades, while omphalocele rates remained stable. This study analyzed abdominal wall defects in 469 infants from 20 birth cohorts (1970-1989).

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Area of Science:

  • Pediatric Surgery
  • Congenital Abnormalities
  • Epidemiology

Background:

  • Increasing global incidence of gastroschisis reported over the past 20-30 years.
  • Omphalocele incidence has not shown similar upward trends.
  • Abdominal wall defects require accurate epidemiological data for understanding causes and outcomes.

Purpose of the Study:

  • To analyze trends in the prevalence of gastroschisis and omphalocele.
  • To investigate changes in the occurrence of abdominal wall defects over time.
  • To provide updated epidemiological data on these congenital anomalies.

Main Methods:

  • Utilized data from three nationwide registries, encompassing 20 birth cohorts from 1970-1989.
  • Included 469 infants with abdominal wall defects, reclassified into gastroschisis, omphalocele, and gross abdominal wall defects.

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  • Estimated registry completeness at 95% for livebirths and 90% for stillbirths.

    • Main Results:

    • Average point prevalence for gastroschisis was 1.33 per 10,000 live and stillbirths.
    • Gastroschisis prevalence showed fluctuations with no significant linear trend over the study period.
    • Average point prevalence for omphalocele was 2.07 per 10,000, with no significant change observed.

    Conclusions:

    • While gastroschisis rates fluctuated, no overall significant linear increase was detected across the entire study period.
    • Omphalocele prevalence remained stable, contrasting with reported increases in gastroschisis.
    • Geographical distribution of both conditions showed no county-specific differences.