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Updated: Sep 21, 2026

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
Published on: February 1, 2017
[Relation between Beta-2-glycoprotein I and hepatitis B virus surface antigen]
Pujun Gao1, Yanjun Guo, Like Qu
1Department of Internal Medicine, the First Affiliated Hospital, Norman Bethune University of Medical Sciences, Changchun 130021, China.
Objective:
To clarify the binding character between Beta-2-glycoprotein I (Beta-2-GPI) and HBsAg.
Methods:
Beta-2-GPI was purified from human plasma and labelled with biotin. Solid phase enzyme linked absorbance assay was used to investigate its binding with HBsAg.
Results:
Biotinylated Beta-2-GPI was found to bind HBsAg and the reaction could be inhibited by excess unlabelled Beta-2-GPI.
Conclusions:
Beta-2-GPI may play a role in hepatitis B virus infection.
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