Iron administration and clinical outcomes in hemodialysis patients

Harold I Feldman¹, Jill Santanna¹, Wensheng Guo¹

¹*Center for Clinical Epidemiology and Biostatistics and the Department of Biostatistics and Epidemiology, Renal Electrolyte and Hypertension Division of the Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania; Pharmaceutical Safety Assessments, Inc., Narberth, Pennsylvania.

Journal of the American Society of Nephrology : JASN

|February 22, 2002

Abstract:

To evaluate the impact of parenteral iron administration on the survival and rate of hospitalization of US hemodialysis patients, a nonconcurrent cohort study of 10,169 hemodialysis patients in the United States in 1994 was conducted. The main outcome measures were patient survival and rate of hospitalization. After adjusting for 23 demographic and comorbidity characteristics among 5833 patients included in multivariable analysis, bills for 10 vials showed a statistically significant elevated rate of death (adjusted RR = 1.11; 95% CI, 1.00 to 1.24; P = 0.05). Bills for 10 vials showed statistically significant elevated risk (adjusted RR = 1.12; 95% CI, 1.01 to 1.25; P = 0.03). Prescribing iron in quantities of 10 vials (1000 mg) of iron dextran over a period of 6 mo.

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Abstract:

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