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Updated: Oct 2, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
Published on: October 22, 2020
Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups
A V Moorman1, E Roman, R A Cartwright
1Leukaemia Research Fund Centre for Clinical Epidemiology, University of Leeds, 30 Hyde Terrace, Leeds LS2 9LN, UK. avm@soton.ac.uk
Abstract:
Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities are also markers of exposure. Our results suggest that the smoking-associated risk for acute myeloid leukaemia is restricted to the t(8;21)(q22;q22) subgroup. This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies.
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